Runs of homozygosity for autozygosity estimation and genomic analysis in production animals
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چکیده
منابع مشابه
Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor
Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome th...
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The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin marriages have long runs of homozygosity (ROH), while the numerous shorter tracts relate to shared ancestry tens and hundreds of generations ago....
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15 صفحه اولGenomic inbreeding estimation in small populations: evaluation of runs of homozygosity in three local dairy cattle breeds.
In the local breeds with small population size, one of the most important problems is the increase of inbreeding coefficient (F). High levels of inbreeding lead to reduced genetic diversity and inbreeding depression. The availability of high-density single nucleotide polymorphism (SNP) arrays has facilitated the quantification of F by genomic markers in farm animals. Runs of homozygosity (ROH) ...
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The availability of high-density panels of genetic polymorphisms has led to the discovery of extended regions of apparent autozygosity in the human genome. At the genotype level, these regions present as sizeable stretches, or 'runs', of homozygosity (ROH). Here, we investigated both the genomic and the geographic distribution of ROHs in a large European sample of individuals originating from 2...
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ژورنال
عنوان ژورنال: Pesquisa Agropecuária Brasileira
سال: 2018
ISSN: 1678-3921,0100-204X
DOI: 10.1590/s0100-204x2018000900001